Last update:
   19-Sep-2022
 

Arch Hellen Med, 39(5),September-October 2022, 647-653

ORGINIAL PAPER

Lack of association between endothelial nitric oxide synthase (eNOS),
G894T gene polymorphism and the risk of bladder cancer,
Α meta-analysis.

K.R. Akbar,1 A.I. Permatasari,1 B. Suwarno,2 J.K. Fajar3
1Faculty of Medicine, Universitas Islam, Malang
2Department of Urology, Faculty of Medicine, Universitas Jember, Jember
3Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas

OBJECTIVE To assess the relationship of bladder cancer risk with eNOS G894T gene polymorphism using meta-analysis.

METHOD The relevant articles were retrieved as of 30 August 2020 from PubMed and ScienceDirect. The associations were estimated using the calculation of pooled odds ratio (OR) and 95% confidence interval (CIs).

RESULTS Four studies, covering a total of 834 cases and 16,80 control subjects, regarding the eNOS G894T gene variant and the risk of bladder cancer were identified and used in our analysis. Our pooled calculation revealed no overall association between the risk of bladder cancer and eNOS G894T gene polymorphism in all genetic modes, including G allele (OR: 0.81 [95% CI: 0.63–1.05], p=0.11), T allele (OR: 1.23 [95% CI: 0.95–1.58], p=0.11), GG genotype (OR: 0.52 [95% CI: 0.25–1.06], p=0.07), GT genotype (OR: 1.59 [95% CI: 0.85–2.98], p=0.143), and TT genotype (OR: 1.15 [95% CI: 0.76–1.73], p=0,51).

CONCLUSIONS Our meta-analysis revealed that the gene polymorphism of eNOS G894T does not affect the risk of bladder cancer.

Key words: Bladder cancer, eNOS G894T, Gene polymorphism, Meta-analysis.

© Archives of Hellenic Medicine