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Arch Hellen Med, 38(6), November-December 2021, 795-797


Fever of unknown origin as the only manifestation of multiple myeloma
A case report

A. Liontos,1 E. Koumpis,2 F. Barkas,1 E. Hatzimichael,2 G. Liamis1
1Department of Internal Medicine, University Hospital of Ioannina, Ioannina
2Department of Hematology, University Hospital of Ioannina, Ioannina, Greece

Infection is the most usual cause of fever in multiple myeloma (MM), but only a few reports have described fever of unknown origin (FUO) as the first manifestation of MM. We present the case of a 67-year-old female with FUO as the only manifestation of MM. In contrast to previously published reports, our patient had no other signs of MM, such as hypercalcemia, renal insufficiency, anemia or bone lesions, nor was her fever attributed to an infection. She presented with FUO, and was found to have leukocytosis, thrombocytosis and raised C-reactive protein (CRP), and the diagnosis of MM was established on bone marrow biopsy. After excluding the usual causes of FUO, therefore, MM might also be considered in its differential diagnosis.

Key words: Fever of unknown origin, Multiple myeloma, Plasma cell myeloma.

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