Last update:
10-Nov-2021

Isotretinoin is an important therapeutic agent, used in the treatment of acne and other skin disorders, which acts on the cell cycle and cell differentiation. It has some serious side effects, however, including autoimmune, hepatic and metabolic disorders, and its association with the occurrence of psychiatric disorders has been documented. This is a review of the clinical studies that correlate isotretinoin with psychiatric disorders, and the pathophysiological mechanisms involved. In addition, other studies report that isotretinoin treatment appears to improve the mood of patients as improvement in the appearance is achieved. Isotretinoin should only be prescribed for severe acne, resistant to other treatments, as it is difficult to predict the sensitivity that patients may manifest as psychiatric side effects. Preprescribing psychiatric assessment and history checking are useful tools for the early detection of adverse psychiatric side-effects. Further scientific studies are necessary to determine the correlation of isotretinoin with psychiatric disorders and to ensure safe, effective treatment with retinoids.

Key words: Depression, Isotretinoin, Psychiatric disorders, Psychosis, Retinoids, Suicide.