Last update:
   23-Jan-2024
 

Arch Hellen Med, 41(1), January-February 2024, 7-16

REVIEW

Aging in Down syndrome: Neurocognitive and clinical profile

E. Mantsos,1 D. Katsarou,2,3 V. Zisi1
1Department of Physical Education and Sport Science, University of Thessaly, Trikala,
2Department of Preschool Education and Educational Design, University of the Aegean, Rhodes,
3School of Education, University of Nicosia, Nicosia, Cyprus

Down syndrome is a dominant neurodevelopmental disorder with a characteristic cognitive and clinical phenotype. Aging follows a special course and the phenomenon of accelerated aging is prevalent. Individuals, i.e., at the age of 25, begin to show cognitive declines, while their neurophysiological development is corresponding. This study attempts a complex approach to the key elements that contribute to the accelerated aging of this population. A synthesis of current research findings in the fields of otolaryngology, cardiology, gastroenterology, endocrinology, hematology, neurocognition and neurology is carried out and conclusions, useful for practical applications, are drawn.

Key words: Aging, Alzheimer, Cognitive decline, Down syndrome, Neurodevelopmental disorder.

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