Last update:
11-Nov-2021

Post-injection delirium/sedation syndrome (PDSS) is a rare adverse effect of long-acting olanzapine injection. The danger of PDSS is not related to the duration of treatment. It may be manifested even after months or years of treatment, but usually presents within the first few minutes of injection, despite meticulous measures of preparation and drug administration. Here, we present two cases of PDSS from our outpatient clinic. The first case was mild and was treated in our clinic. The second case was severe and necessitated transfer of the patient to an emergency medical department. Both patients continue monitoring in our clinic, without manifesting adverse effects again.

Key words: Adverse effects, Case report, Long-acting antipsychotics, Long-acting olanzapine, Post-injection delirium/sedation syndrome.