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15-Jan-2020
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Arch Hellen Med, 37(1), January-February 2020, 66-71 ORIGINAL PAPER Comparative study of polymorphisms in the development of obesity in Greece Μ. Michaloudi, Μ. Chouzouris, K. Politis |
OBJECTIVE To examine the association of specific single nucleotide polymorphisms with obesity.
METHOD The study was based on a database of information on polymorphisms collected from volunteers over a period of three years (2013–2016) by the clinical pharmacology research team of the Department of Pharmacy of the National and Kapodistrian University of Athens. Data on a total of 406 individuals of both sexes, ranging in age from 16 to 89 years were analyzed in the study. The Statistical Package for Social Sciences (SPSS), version 24.0, was used for the statistical analysis.
RESULTS The analysis showed that of five single nucleotide polymorphisms investigated, only one polymorphism, namely ADRB1rs1801253, was correlated with weight. Both gender and age influenced the likelihood of being classified as obese. Through non-parametric analysis, it was observed that only the gender affected the weight, and specifically, the male sex had the highest body mass index (29.79).
CONCLUSIONS On study of five single nucleotide polymorphisms, only polymorphism ADRB1rs1801253 showed a statistically significant relationship with obesity. Both sex and age influence the likelihood of individuals being classified as obese.
Key words: Body mass index, Greece, Obesity, Polymorphisms.
