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Arch Hellen Med, 30(2), March-April 2013, 212-219


Estimation of resistin in chronic kidney disease

H. Abou-Youssef,1 S. Kholoussi,2 M. Ishak,1 N. Kholoussi,2 F. ElZahraa Ahmed2
1Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo
2Department of Immunogenetics, Division of Human Genetics, National Research Center, Cairo, Egypt

OBJECTIVE To compare the serum level of resistin in patients with chronic kidney disease (CKD) with that of normal control subjects and to elucidate the association of resistin with insulin resistance and markers of inflammation in CKD.

METHOD Study was made of 60 patients with CKD according to the National Kidney Foundation practice guidelines and 20 apparently healthy control subjects in the age range, 46−70 years. Obese individuals and those with diabetes mellitus were excluded. Measurements were made of fasting plasma glucose and serum levels of triglycerides, total cholesterol, creatinine, C-reactive protein (CRP), resistin and insulin, followed by calculation of estimated glomerular filtration rate (eGFR) and homeostasis model assessment (HOMA).

RESULTS The levels of resistin, insulin and CRP and HOMA were all higher in patients with CKD than in the control subjects (p<0.05). The serum level of resistin was higher in patients with stage 5 than in those with stage 4 CKD (p<0.05). Patients with elevated CRP (>6 mg/L) had statistically significantly higher resistin levels than those with lower CRP (<=6 mg/L). Positive correlation was demonstrated between serum level of resistin and the levels of insulin and creatinine (r=0.856, r=0.302, respectively, p<0.05) and negative correlation between serum resistin and eGFR (r=-0.285, p<0.05).

CONCLUSIONS Resistin was found to be associated with CKD and its blood level increased with progressive impairment of renal function. Resistin was correlated with CRP in CKD and this may be indicative of a link with metabolic and cardiovascular complications.

Key words: CKD, CRP, HOMA, Insulin, Resistin.

© Archives of Hellenic Medicine