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Arch Hellen Med, 2008, 25(Supplement 2):7-35


Adhesion molecules; novel tools in the cancer jigsaw

Department of Physiology, Clinical Unit, Medical School, University of Ioannina, Ioannina, Greece

In the present study the topic of adhesion molecules regarding their involvement in the whole carcinogenetic process is discussed in detail. Until now, more than a hundred adhesion molecules have been fully identified, and their role so in normal as in various pathologies, including cancer, is under continuous investigation. Adhesion molecules are involved so in the initial invasive carcinogenetic process, as in the metastatic foci creation. The role of some members of integrins, cadherins, immunoglobulin gene superfamily, selectins and CD44 that comprise adhesion molecules is discussed. Their role in diagnosis, prognosis, and possibly in treatment, is also referred.

Key words: Adhesion molecules, Cancer, Integrins, Cadherins, Immunoglobulin gene superfamily, Selectins, CD44.

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