Last update:
09-Mar-2009

Following the introduction of serum γ-GT in clinical practice as a reliable, routinely employed laboratory test, epidemiological and prospective studies have repeatedly shown that this activity has prognostic value for morbidity and mortality. Notably, a significant independent correlation of serum γ-GT is observed with cardiovascular disease (myocardial infarction, stroke, diabetes mellitus, and metabolic syndrome) and this association is independent of concomitant liver disease. Experimental studies have documented the presence of active γ-GT in atherosclerotic plaques in the coronary and cerebral arteries. These findings and the recently recognized functions of γ-GT in the generation of reactive oxygen species indicate that serum γ-GT represents a true marker of cardiovascular disease and underlying atherosclerosis.

Key words: Atherosclerosis, Atherosclerotic plaque, Cardiovascular disease, Gamma-glutamyltransferase.