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Arch Hellen Med, 23(5), September-October 2006, 501-506


The association of serum leptin with biochemical parameters of bone turnover in maintenance hemodialysis patients

1Shahrekord University of Medical Sciences, Hajar Medical, Educational and Therapeutic Center, Department of Internal Medicine, Shahrekord, Iran
2Department of Biochemistry, Center of Research and Reference Laboratory of Iran, Hospital Bu-Ali, Tehran, Iran

OBJECTIVE Leptin is a small peptide hormone that is mainly, but not exclusively, produced in adipose tissue and cleared principally by the kidney. Serum leptin concentrations and bone mass are directly related. This cross-sectional study was conducted on patients with end-stage renal disease (ESRD), who were undergoing maintenance hemodialysis (HD).

METHOD Serum calcium, phosphorus, predialysis serum creatinine, blood urea nitrogen, alkaline phosphatase (ALP), intact serum PTH (iPTH) and serum leptin were measured in 36 dialysis patients, 10 of whom were diabetic.

RESULTS A significant difference in serum leptin between male and female diabetic patients was seen with higher values in females. In all patients a significant positive correlation of the logarithm of serum leptin with the logarithm of serum iPTH and a significant positive correlation of serum leptin with body mass index (BMI) were found. In male HD patients a near significant and inverse correlation of serum ALP with serum leptin was seen. In female HD patients a near significant inverse correlation of serum leptin with serum phosphorus and a significant inverse correlation of serum leptin with CaP products were found.

CONCULSIONS In HD patients serum leptin affects bone activity.

Key words: Alkaline phosphatase, Bone turnover, Hemodialysis, PTH, Serum leptin.

© Archives of Hellenic Medicine