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Arch Hellen Med, 19(5), September-October 2002, 568-572


Type II heparin induced thrombocytopenia with thrombosis
of pulmonary artery and multiple pulmonary embolism

Hemostatic Unit, 1st Propedeutic Department of Internal Medicine, AHEPA Hospital,
Aristotelian University of Thessaloniki, Medical School, Thessaloniki, Greece

The case is reported of a 63 year old male who presented with heparin-induced thrombocytopenia type-II (HITII) due to low molecular weight heparin treatment. He had serious thromboembolic complications (pulmonary artery thrombosis and multiple pulmonary emboli). The amelioration of clinical manifestations after application of alternative anticoagulant treatment (lepirudine) is emphasised. The two types of HIT with their clinical features are presented and their pathophysiology is interpreted. Particular emphasis is given to the use of modern anticoagulant medicines (Refludan, Orgaran) which may be used for the prevention and/or the treatment of HIT.

Key words: Heparin, Heparin induced thrombocytopenia, Pulmonary embolism.

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